During the COVID-19 pandemic, HKU-SZH has made numerous achievements in the research of the novel coronavirus, including its origin, transmission, early detection, early diagnosis, risk stratification, treatment strategies, drug R&D, and infection control inside and outside the Hospital. 37 papers were published in Lancet, NEJM, Nature, Cell, and other journals by either the lead author or corresponding author from the Hospital, with the total impact factor exceeding 360. In view of the outstanding contribution to COVID-19 prevention and control, HKU-SZH was awarded the first prize of the Shenzhen Science and Technology Progress Award in the social welfare category for its "Application of Clinical Microbiology and Imaging in the Prevention and Treatment of COVID-19 infections" in 2021.